the easy answer is what size wheel is on the bike, which comes back to what others were saying about what the bike was designed for. 180's are meant fora 5.5" wide wheel. 160's are meant for a 4.5" wheel. Yeah, there's some fudge factor there when folks decide to go up or down one size of tire, but then you get into issues of tire deformation as you squeeze or stretch a tire to fit on a rim it wasn't designed for. To some folks, its no big deal, but it would be for me.