I started on a 250 and bumped up to an 03 R6 last year with one year of riding under my belt--no problem at all...I had it lowered to with a dogbone about 2.5 inches or so and that works for me although I may move it back up some now...the triple tree was already lowered when I bought the bike so it needed to be lowered in the back with the dogbone as well.
I am 5'4" and I have the balls of my feet on the ground at a stop--so it is quite comfortable. You could also shave the seat off too--the foam underneath it..that will lower the seat somewhat and that will help her too
