Viruses and other exploits almost all function at the OS level. That means that Windows itself is the vulnerability, not the Mac or x86 based hardware.
From an IT/InfoSec perspective, Windows isn't that bad...with the giant caveat that it needs to remain properly patched and utilize appropriate security settings. Unpatched, its a nightmare. WinXP SP2 and 2003 Server have come a long way in terms of having the right security settings enabled out of the box. If people go ahead and circumvent them, that's their own fault.
The other reason windows is more succeptible to attack is the userbase; there's a ton more people using windows-based OS (of any flavor) than MacOS (of any flavor). Same with Linux variants. If one of the other OS somehow took the forefront (not likely, since people are resistant to change), then that OS would be the target of the most attacks.
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